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* $10M milestone payment from Merck induced * Agenus is qualified for around an additional $85 million in milestones moreover royalties on salesLEXINGTON, Mass., Nov. ten, 2020 (World NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an in depth pipeline of checkpoint antibodies, mobile therapies, adjuvants, and vaccines created to activate immune response to cancers and infections, right now announced that a milestone payment of $10M from Merck has long been triggered with the advancement of an ILT4 antibody, MK-4830, into a Section 2 scientific trial. Agenus learned this novel checkpoint antibody, built to concentrate on immune-suppressive myeloid cells from the tumor microenvironment with the procedure of State-of-the-art strong tumors, and accredited the molecule to Merck.“Novel myeloid mobile targeting antibodies have the possible to take care of people who at this time don't take advantage of primary checkpoint antibodies,” mentioned Garo Armen, Chairman and CEO of Agenus. “We are enthusiastic about the development of MK-4830 and anticipate providing our very own wholly-owned novel myeloid tuning agent on the clinic next year.”Merck is analyzing MK-4830 together with KEYTRUDA® (pembrolizumab) in a very Stage 2 study in sufferers with PD-L1 beneficial State-of-the-art non-modest mobile lung cancer (NCT04165083) with data presented at ESMO earlier this 12 months: the phrases with the agreement, Merck is chargeable for all item enhancement expenditures for MK-4830 and Agenus is qualified to get approximately $eighty five million in more potential milestone payments, along with royalties on worldwide item sales. Below its Royalty Purchase Agreement with XOMA LLC, Agenus retains 90% of all milestones from Merck and sixty seven% of upcoming royalties.About Agenus Agenus is a medical-stage immuno-oncology business focused on the invention and development of therapies that interact the body's immune program to fight cancer. The organization's vision is always to increase the affected person populations benefiting from cancer immunotherapy by pursuing mix strategies that leverage a wide repertoire of antibody therapeutics, adoptive cell therapies (as a result of its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms.

”Dr. Joseph Grossman lately joined Agenus as head of exploratory medicine from Harvard Professional medical College, wherever he was an teacher in medicine, and Beth Israel Deaconess Healthcare Centre, wherever he served as an attending doctor in GI oncology. He concluded his residency and fellowship in hematology oncology at Beth Israel Deaconess Professional medical Heart. He holds a postbaccalaureate certificate in premedical sciences from Columbia University in the town of The big apple and an MD from Brown Medical University.About Agenus Agenus is actually a medical-stage immuno-oncology company focused on the invention and advancement of therapies that have interaction your body's immune process to struggle most cancers. The corporate's vision is to extend the affected person populations benefiting from cancer immunotherapy by pursuing mix ways that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (via its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms. The business is equipped with a set of antibody discovery platforms as well as a Slot Online condition-of-the-art GMP producing facility Together with the potential to support medical applications. Agenus is headquartered in Lexington, MA. For more info, please stop by and our Twitter take care of @agenus_bio. Information and facts Which might be imperative that you investors is going to be routinely posted on our Web page and Twitter.Forward-Looking Statements This push release incorporates ahead-looking statements that are made pursuant into the safe harbor provisions of the federal securities legislation, which includes statements concerning the therapeutic and curative likely of AGEN1181. These forward-hunting statements are subject matter to hazards and uncertainties that may trigger precise results to vary materially. These risks and uncertainties consist of, among the Other people, the elements described beneath the Chance Variables area of our most recent Quarterly Report on Type ten-Q or Yearly Report on Type ten-K filed Along with the Securities and Trade Fee. Agenus cautions traders not to put substantial reliance to the forward-hunting statements contained In this particular release. These statements converse only as with the day of this press launch, and Agenus undertakes no obligation to update or revise the statements, besides into the extent demanded by regulation. All ahead-looking statements are expressly certified in their entirety by this cautionary assertion.Get hold of: Agenus Inc. Caroline Bafundo 212-994-8209 [email protected]

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